Tiziana Life Sciences announces the grant of share options to directors and members of senior management.

15th March 2023

Grant of share options

NEW YORK, March 15, 2023 — Tiziana Life Sciences Ltd. (Nasdaq: TLSA) (“Tiziana” or the “Company”), a biotechnology company developing breakthrough immunomodulation therapies via novel routes of drug delivery, today announced the grant of the following share options to directors and members of senior management:

Matthew Davis

Chief Medical Officer and acting Chief Scientific Officer

375,000 Options

Keeren Shah

Chief Financial Officer

187,500 Options

Jules Jacob

Executive Director of Chemistry, Manufacturing, Controls & Non-Clinical Development

85,000 Options

Vaseem Palejwala

Senior Director, Clinical Operations

60,000 Options

John Brancaccio

Non-executive director

75,000 Options

Willy Simon

Non-executive director

75,000 Options

The exercise price for all options is $0.57 per share. The options all vest in 4 equal tranches over 4 years, with the first tranche vesting on 15 March 2024, and all options have a life of ten years from date of grant.

About Foralumab

Activated T cells play an important role in the inflammatory process. Foralumab, the only fully human anti-CD3 monoclonal antibody (mAb), binds to the T cell receptor, dampens inflammation by modulating T cell function, thereby suppressing effector features in multiple immune cell subsets, an effect demonstrated in patients with COVID and with multiple sclerosis, as well as in healthy normal subjects. Intranasal foralumab Phase 2 trials are expected to start in Q3 2023 in patients with non-active SPMS. Immunomodulation by nasal anti-CD3 mAb represents a novel avenue for treatment of inflammatory human diseases.1



About Tiziana Life Sciences

Tiziana Life Sciences is a clinical-stage biopharmaceutical company developing breakthrough therapies using transformational drug delivery technologies to enable alternative routes of immunotherapy. Tiziana’s innovative nasal, oral and inhalation approaches in development have the potential to provide an improvement in efficacy as well as safety and tolerability compared to intravenous (IV) delivery. Tiziana’s lead candidate, intranasal foralumab, the only fully human anti-CD3 mAb, has demonstrated a favorable safety profile and clinical response in patients in studies to date. Tiziana’s technology for alternative routes of immunotherapy has been patented with several applications pending and is expected to allow for broad pipeline applications.

For further inquiries:

Tiziana Life Sciences Ltd

Paul Spencer, Business Development and Investor Relations
+44 (0) 207 495 2379


Irina Koffler
LifeSci Advisors, LLC