Developing innovative drugs for the treatment of Crohn's Disease, COVID-19, Progressive Multiple Sclerosis (pro-MS) and Hepatocellular Carcinoma (HCC)

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Issue of Equity on Exercise of Warrants

20 October 2020

London, New York, 20 October 2020 - Tiziana Life Sciences plc (Nasdaq: TLSA / AIM: TILS) ("Tiziana" or the "Company"), a biotechnology company focused on innovative therapeutics for oncology, inflammation and infectious diseases, today announces that it has allotted and...

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Result of General Meeting

02 October 2020

At the General Meeting of the Company held at 11.00 a.m. on 2 October 2020, both of the resolutions were duly passed.

The anticipated timetable for the demerger of Accustem Sciences Limited (to be re-registered as Accustem Sciences Plc) is as...

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Interim Results for the Six Months Ended 30 June 2020

30 September 2020

London, 30 September 2020 – Tiziana Life Sciences plc (“Tiziana”, AIM: TILS, NASDAQ: TLSA), a biotechnology company that focuses on the discovery and development of novel molecules to treat human diseases in oncology, inflammation and infectious diseases today announces its interim results for the six months ended 30 June 2020.

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Our Mission

Our mission is to bring breakthrough therapies to patients with the aim of treating Crohn's Disease, COVID-19, Pro-MS and HCC and optimizing health outcomes.

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Clinical Candidates

With two Phase II and two pre-clinical candidates our development portfolio is supported by extensive IP and a strong pipeline of in-licensed clinical and pre-clinical assets.

Clinical development pipeline

Foralumab

Foralumab is a fully human anti-CD3 monoclonal antibody (mAb) for treatment of Crohn’ s Disease and a neurodegenerative indication.

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Milciclib

Milciclib is the Company’s Phase 2 clinical candidate for the treatment of multiple cancer indications such as hepatocellular carcinoma, thymic cancer and thymoma.

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Pre-Clinical Candidates

With several candidates being prepared for clinic, our development portfolio is supported by extensive IP and a strong pipeline of in-licenced clinical and pre-clinical assets.

Anti IL-6R mAb (TZLS-501)

We are developing a fully human monoclonal antibody (mAb) targeting the receptor for IL-6 as a potential treatment for certain patients infected with COVID-19.

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StemPrintER™

StemPrintER is a multi-gene signature assay intended for use as a prognostic in patients with estrogen-receptor positive ER+/HER2 negative breast cancers.

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Clinical Trials

Tiziana is currently conducting clinical development programs for Foralumab and Milciclib

Foralumab

Tiziana reported postive clinical data in a Phase I clinical trial of nasally-dosed Foralumab in healthy subjects in collaboration with Dr. Howard Weiner at Brigham and Women’s Hospital in Boston. Phase 2 for both orally administered Foralumab for the treatment of Crohn's disease and nasally administered Foralumab for the treatment of Pro-MS is anticipated to be complete in Q2 2021.

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Milciclib

We reported positive Phase 2a clinical data exhibiting positive clinical activity with Milciclib Monotherapy in advanced Sorafenib-refractory or -intolerant Patients with Unresectable or Metastatic Hepatocellular Carcinoma. We intend to initiate Phase 2b with Milciclib in Combination with a TKI in Q2 2021

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Tiziana Life Sciences is listed on NASDAQ and AIM