Technology
Foralumab
A Novel Intranasal Immunotherapy to Reduce Neuroinflammation
Intranasal foralumab is successfully delivered to the cervical lymph nodes through a convenient nasal administration.
Here it binds to the surface of a CD4+ or a CD8+ T Cell
This stimulates the development of anti-inflammatory producing IL-10 T Regs
These T Regs migrate into the CNS where they infiltrate the blood brain barrier and produce IL-10 to promote a switch in the activated microglial state to a anti-inflammatory homeostatic state.
These IL-10 also suppress other cells of the CNS including astrocytes which reduces blood brain barrier degradation
These mechanisms help defend the CNS against chronic inflammatory damage.