Change to ADS Ratio – Updated

15th July 2020

New York/London, 15 July 2020 – Tiziana Life Sciences plc (“Tiziana”, AIM: TILS, NASDAQ: TLSA), announces a ratio change to its sponsored Level 3 American Depositary Receipt (“ADR”) programme.

Please note that pursuant to the announcement earlier today, to effect the change to the ADR ratio, ADR holders will receive 1.5 additional ADRs for every one (1) ADR held as of 27 July 2020, the ADR record date (and not 2.5 additional ADSs as previously stated).

The timetable remains as previously stated.

Existing ADRs will continue to be valid and will not have to be exchanged for new ADRs. In connection with this change, the register held by JPMorgan will be closed for issuances and cancellations from the close of business 27 July 2020 and will reopen on 04 August 2020.

For further information, please contact:

JPMorgan Service Centre ADR Settlements

001 800-990-1135 or 001 302-552-0230

About Tiziana Life Sciences

Tiziana Life Sciences plc is a dual listed (NASDAQ: TLSA & UK AIMS: TILS) biotechnology company that focuses on the discovery and development of novel molecules to treat human diseases in oncology, inflammation and infectious diseases. In addition to milciclib, the Company will be shortly initiating phase 2 studies with orally administered foralumab for Crohn’s Disease and nasally administered foralumab for progressive multiple sclerosis. Foralumab is the only fully human anti-CD3 monoclonal antibody (mAb) in clinical development in the world. This phase II compound has potential application in a wide range of autoimmune and inflammatory diseases, such as Crohn’s Disease, multiple sclerosis, type-1 diabetes (T1D), inflammatory bowel disease (IBD), psoriasis and rheumatoid arthritis, where modulation of a T-cell response is desirable. The company is accelerating development of anti-Interleukin 6 receptor (IL6R) mAb, a fully human monoclonal antibody for treatment of IL6-induced inflammation, especially for treatment of COVID-19 patients.

For further enquiries:

Tiziana Life Sciences plc

Gabriele Cerrone, Chairman and founder

+44 (0)20 7495 2379

Cairn Financial Advisers LLP (Nominated adviser)

Liam Murray / Jo Turner

+44 (0)20 7213 0880

Optiva Securities Limited (Broker)

Robert Emmet

+ 44 (0)20 3981 4173